Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older
이지현, 신민호, 권순석, 이영훈, 김옥준, 김영준, 정현주, 김옥수,
소속 상세정보
이지현 ( Lee Ji-Hyun ) - Chonnam National University School of Dentistry Department of Periodontology
신민호 ( Shin Min-Ho ) - Chonnam National University Medical School Department of Preventive Medicine
권순석 ( Kweon Sun-Seog ) - Chonnam National University Medical School Department of Preventive Medicine
이영훈 ( Lee Young-Hoon ) - Wonkwang University Medical School Department of Preventive Medicine
김옥준 ( Kim Ok-Joon ) - Chonnam National University School of Dentistry Department of Oral Pathology
김영준 ( Kim Young-Joon ) - Chonnam National University School of Dentistry Department of Periodontology
정현주 ( Chung Hyun-Ju ) - Chonnam National University School of Dentistry Department of Periodontology
김옥수 ( Kim Ok-Su ) - Chonnam National University School of Dentistry Department of Periodontology
KMID : 0353420170410010015
Abstract
The association between periodontal disease and cardiovascular disease (CVD) has received considerable attention. This study investigated the correlation between tooth loss (the chief clinical parameter of periodontal disease) and systemic biomarkers of CVD, C-reactive protein (CRP) levels, and leukocyte (WBC) counts, in Koreans aged 50 years or older. A cross-sectional data of 5,322 participants was obtained from the 2008 to 2010 Dong-gu Study. Oral examination, survey questionnaire, physical examination, and biochemical assessments were performed. Oral examinations were completed in all dentate participants, and included the percentage of sites with ≥ 4 mm of probing depth (PD4%), clinical attachment level ≥ 4 mm (CAL4%), and bleeding on probing (BOP%). The number of missing teeth was categorized as 0-7, 8-15, 16-31, and edentulous. The serum CRP levels and WBC counts were assessed. Multivariate linear regression analysis was performed after adjusting for other potential confounders, to evaluate the association between the clinical parameters of periodontal disease, CRP levels and WBC counts. In the fully adjusted model, PD4%, BOP% and the number of missing teeth positively correlated with the CRP levels (p < 0.05), but CAL4% did not. The PD4%, CAL4%, and BOP% (p < 0.05) were concomitant with the WBC counts, but the number of missing teeth was not. The clinical parameters of periodontal disease and tooth loss directly correlated with CRP levels and WBC count in adults aged 50 years and above. This association indicates the potential significance of periodontal inflammatory burden for systemic inflammation.
키워드
C-reactive protein; Leukocytes; Periodontal disease; Tooth loss
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